Kate McCann has revealed that she struggled to control Madeleine McCann after the birth of her and Gerry's twins, it was revealed today.

Missing Madeleine would run around 'screaming...shouting for my attention', the mother-of-three said.

In an interview given to a Portuguese magazine before she was named as a suspect in the case of the four-year-old's disappearance, Kate also said the first six months of Madeleine's life were "very difficult" and that the girl had suffered from colic.

Gerry and Kate McCann in sombre mood today

The revelations come as police said they were trawling through Kate's medical records amid suspicions in Portugal that she may have had a history of depression.

The detailed analysis of her medical notes could provide them with significant evidence against the GP, who is a suspect in the case of Madeleine's disappearance.

Speaking about Madeleine's upbringing, Kate, a 39-year-old GP, told Portugal's Flash! magazine: "She cried practically for 18 hours a day. I had to permanently carry her around."

Kate McCann with twins Sean and Amelie

This period explained "the strong bond between mother and daughter", she said.

Although the arrival of the twins Sean and Amelie shook up Madeleine's life, she accepted them very well, said Kate.

"She managed to deal perfectly with this new reality, although she herself at the time was still a baby.

"The worst thing is that she started to demand lots of attention, especially when I was breast-feeding them.

Madeleine McCann: Would run around screaming and demanding attention after her twin brother and sister were born

"She would run up and down screaming in the background, shouting for my attention."

Mrs McCann also insisted that she and her husband were "truly responsible parents" and had committed no crime.

Speaking of the night Madeleine disappeared, she said: "I was sure immediately that she didn't walk out of that room. I never doubted that she had been taken by someone.

"I went through a phase of guilt for not knowing what happened to her. I blamed myself for thinking that the place was safe.

"But the certainty that we are truly responsible parents has helped me carry on.

"I know that what happened is not due to the fact of us leaving the children asleep. I know it happened under other circumstances."

Asked about whether she and her husband were responsible for their daughter's disappearance, she said: "It cannot be considered a crime. Someone committed one, but not us."

Portuguese newspapers continued to report today that Mrs McCann will be re-interviewed in the UK this week by British police on behalf of the Algarve authorities.

But a spokeswoman for the McCanns said the couple had to date received no request for new interrogation.

The judge in the case, Pedro Daniel dos Anjos Frias, rejected prosecutors' request to have the McCanns brought back to Portugal for further questioning, the Correio da Manha said.

He insisted that the fresh interviews should be carried out by British police in the UK, according to the paper.

The re-interviewing will only take place when further DNA testing in Birmingham is completed, either tomorrow or Wednesday.

A letter of appeal will be sent to Britain, setting out all the questions Portuguese detectives want to ask the couple, along with the evidence supporting their hypothesis, the Correio da Manha reported.

A source told the paper there was only a "very low" probability that Portuguese officers would be allowed to sit in on the interviews.

A McCann family spokeswoman said today: "We have been in touch with the lawyers to try and get a steer on what is in the Portuguese papers.

"They assure us we have had no request to date for any further questioning, either from the Portuguese police or in the UK."

She could not say whether the McCanns' legal team was expecting the couple to be re-interviewed.

Since Kate and Gerry McCann were named as official suspects last week, there have been suggestions in Portugal that Madeleine was given drugs on the night of her disappearance.

The accusations have been strenuously denied by the couple but have not been ruled out by police. Although the order to seize medical files came from the Portuguese authorities, the background searches are being carried out by Leicestershire police.

A copy of Mrs McCann's diary has also been seized by police, who are now waiting for permission from the judge to seize and dismantle the McCanns' hire car so they can search for "traces of skin".

It has been reported that DNA evidence with a match to Madeleine was found in the Renault Scenic 25 days after their daughter vanished.

Yesterday it emerged the McCanns are trying to knock down potential evidence retrieved after two British sniffer dogs, capable of detecting blood and human remains, were used in the investigation in August.

One of the dogs picked up a "scent of deathî on items ranging from Mrs McCann's clothes to Madeleine's favourite soft toy Cuddle Cat.

Leaked reports from the investigation have suggested that Madeleine's parents could have accidentally killed her and then disposed of her body using the car. Although they do not know the full details of the Portuguese prosecutors' case against them, the McCanns are concerned that it may rest on the dog's reaction.

The couple's legal team has now consulted the lawyers of an American man accused of murdering his estranged wife in a case where "cadaver dog" evidence was central. They want to highlight the judge's dismissal of such evidence in the high-profile Eugene Zapata murder trial in Madison, Wisconsin.

Mr Zapata's estranged wife, flight instructor Jeanette Zapata, was 37 when she vanished in October 1976 after seeing her three children off to school.

Her body has never been found. Detectives suspected Mr Zapata of involvement in her disappearance but did not charge him because of a lack of evidence.

Police decided to conduct new searches using cadaver dogs and Mr Zapata, 68, was charged with firstdegree murder last year after the dogs indicated that they had scented human remains in an underfloor crawl space at the former family home and other properties linked to him.

But the judge ruled that the dogs' ability to detect remains was too unreliable, noting that no remains had actually been found.